Celine Shi Selected Research

WYE 125132

5/2010	Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells.
1/2010	Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Celine Shi Research Topics

Disease

9	Neoplasms (Cancer) 05/2016 - 01/2004
2	Breast Neoplasms (Breast Cancer) 05/2016 - 01/2004
1	Hypoxia (Hypoxemia) 01/2010
1	Glioma (Gliomas) 01/2010

Drug/Important Bio-Agent (IBA)

4	Sirolimus (Rapamycin)FDA Link 05/2016 - 08/2009
3	Mechanistic Target of Rapamycin Complex 2IBA 05/2016 - 08/2009
3	Mechanistic Target of Rapamycin Complex 1IBA 05/2016 - 08/2009
3	Phosphotransferases (Kinase)IBA 05/2010 - 08/2009
2	WYE 125132IBA 05/2010 - 01/2010
2	temsirolimus FDA Link 05/2010 - 01/2010
2	MTOR InhibitorsIBA 01/2010 - 08/2009
1	Acetyl Coenzyme A (Acetyl-CoA)IBA 05/2016
1	ATP Citrate (pro-S)-Lyase (Citrate Synthase, ATP)IBA 05/2016
1	Amino Acid Transport Systems (Amino Acid Transporter)IBA 07/2015
1	Small Interfering RNA (siRNA)IBA 07/2015
1	Essential Amino AcidsIBA 07/2015
1	Large Neutral Amino Acid-Transporter 1IBA 07/2015
1	Methionine (L-Methionine)FDA Link 07/2015
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 04/2014
1	RNA Polymerase IIIIBA 05/2010
1	Cytotoxins (Cytolysins)IBA 05/2010
1	TOR Serine-Threonine KinasesIBA 01/2010
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2010
1	Bevacizumab (Avastin)FDA Link 01/2010
1	Proteins (Proteins, Gene)FDA Link 01/2010
1	Antineoplastic Agents (Antineoplastics)IBA 01/2010
1	Biomarkers (Surrogate Marker)IBA 01/2010
1	WYE-354IBA 08/2009
1	HTI-286IBA 05/2005
1	hemiasterlinIBA 05/2005
1	Paclitaxel (Taxol)FDA LinkGeneric 05/2005
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 05/2005
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2004
1	EKB 569IBA 01/2004
1	ErbB Receptors (EGF Receptor)IBA 01/2004
1	Epidermal Growth Factor (EGF)IBA 01/2004
1	Mitogen-Activated Protein Kinase 3IBA 01/2004
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2004

Therapy/Procedure

4	Therapeutics 04/2014 - 02/2008
1	Oral Administration 01/2010